A thorough understanding of these practical considerations in the lab will help ensure successful results with this technique
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The water-soluble nature means that passive diffusion can occur when very high doses are consumed orally , which is why high-dose oral supplements (1,0002,000 micrograms) can be effective even in patients with impaired intrinsic factor production
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PubMed Garvey, W.T., Batterham, R.L., Bhatta, M., Buscemi, S., Christensen, L.N., Frias, J.P., et al
The 2mg dose balances effectiveness with efficiency