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Its discovery, published in Cell Metabolism (Lee et al., 2015), established it as a key regulator of glucose metabolism and insulin sensitivity

semaglutide at maintenance doses of 0.5 mg, 1.0 mg or 2.0 mg once weekly for a minimum duration of 12 weeks

Corrao G, Mancia G (2015) Generating evidence from computerized healthcare utilization databases

This week in Nature Neuroscience Andrea Serino and colleagues published the results of 248 healthy volunteers who underwent virtual reality to see human avatar faces categorizing persons with signs of infection (coughing, rashes), one of fear, and another of neutrality (Neural anticipation of virtual infection triggers an immune response.)

For every 10 pounds lost, A1C typically improves by 0.3-0.5% independent of any medication effect

Their anti-obesity effects are primarily driven by the appetite suppression associated with nutritional ketosis and increased dietary protein intake, both of which contribute to reduce energy intake