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March 14 Product: Madrigals Rezdiffra Indication: MASH In one of the years most highly anticipated FDA decisions, Madrigal Pharmaceuticals won approval Thursday for resmetiromhenceforth to be known as Rezdiffraas the first-ever treatment for metabolic dysfunction-associated steatohepatitis (MASH), formerly noncirrhotic non-alcoholic steatohepatitis (NASH)

Accessed July, 2025

References Hira, T

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Renal proteomic analysis The kidney samples from GK and GK+Sita rats (n=6, each group) were powdered and dissolved in lysis buffer (7 M urea, 2 M thiourea, 4% Chaps and 30 mM Tris pH 8.5) containing 50 mM dithiothreitol (DTT) and additionally broken with the 2D Grinding Kit (GE Healthcare, Little Chalfont, UK), following the manufacturers instructions

This aligns with user reports of stabilized improvements by month 4